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KMID : 0363219770150010039
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Korean Journal of Dermatology
1977 Volume.15 No. 1 p.39 ~ p.43
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A Study on Therapeutic Evaluation with Econazole in Patients with Dermatomycoses and In Vitro Determination of Minimal Inhibitory Concentration
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金鍾敏/Kim, Jong Min
殷熙哲/李昌雨/金洪植/Eun, Hee Chul/Lee, Chang Woo/Kim, Hong Sik
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Abstract
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Econazole is one of the new imidazole derivatives displaying antifungal and antibacterial properties in vitro and in vivo.
The present study was undertaken to evaluate the therapeutic efficacy of Econazole in patients with dermatomycoses and to determine the minimal inhibitory concentration in vitro.
A total of 48 patients with various forms of dermatomycoses(25 patients with T. cruris, 13 with T. pedis, 1 with T. corporis, 4 with T. versicolor and 5 with candidiasis) entered this study at the Departement of Dermatology, University Hospital, College of Medicine, Seoul National University during 3 months´ period from July to September, 1976. Diagnosis was established clinically as well as microscopically by direct KOH mount.
All patients were instructed to apply 1 % Econazole solution two to three times daily on the affected area for four to seven weeks and weekly examination of the clinical lesions and direct KOH mount were performed.
In addition, minimal inhibitory concentration for Trichophyton mentagrophytes was determined by the modified dilution technique in vitro. The results were as follows.
1. Thirty five patients (72.9%) were cured clinically and microscopically and the remainders showed marked clinical improvement but positive KOH mount at 4 th week of treatment. At 7th week, nine (18.8%) of the remainders were cured clinically and microscopically and the overall cure rate at 7th week was 91.7 %.
Five patients with tinea cruris experienced transient irritation dermatitis on their crural regions.
2. The minimal inhibitory concentration of Econazole for Trichophyton mentagrophytes was 25 ㎍ per ml. of medium.
The authors concluded that the 1 % Econazole was highly effective in the treatment of superficial mycoses and the side effects were minimal and only transient.
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